Publication Title:

MARION N. ONG’AYO1, GEORGE O. OSANJO2, MARGARET OLUKA3. ADHERENCE TO ANTI-TUBERCULOSIS TREATMENT AMONG PAEDIATRIC PATIENTS AT KENYATTA NATIONAL HOSPITAL

Abstract:

Background Tuberculosis remains a major cause of morbidity and mortality worldwide and is the most common cause of death from a single infectious disease particularly in children. Adherence to anti-tuberculosis medication throughout the six month treatment period is extremely important if the treatment for TB is to be successful. Objective To determine the rate of patient adherence to anti-tuberculosis treatment and to determine the factors which affect adherence to treatment in TB paediatric patients. Methodology This was a hospital based cross sectional study which was carried out at the Kenyatta National Hospital (KNH) TB clinic. 57 caregivers of children aged 0 to 15 years who met the inclusion criteria were sampled. The caregivers were interviewed using a structured questionnaire. After the interview the patients were requested to provide a urine sample which was tested for the presence of INH or its metabolites to verify adherence to anti-tuberculosis medication. Results The rate of adherence to anti-TB medications as determined by urine testing was 91.8 %. Marital status was found to be an economic and structural factor that is significantly associated with adherence to medication. Among the patient/caregiver factors, administration of medicine at 24 hour intervals was significantly associated with adherence to medication. Bivariate analysis showed that patients whose caregivers were married or administered medication at 24 hour intervals were more likely to adhere to medication. The ORs (95% CIs) were 4.57 (1.04 - 20.11) and 7.70 (1.85 - 33.33) respectively. In multivariate analysis, administration of medication at 24 hour intervals was significantly associated with adherence to medication (OR: 6.47; 95% CI 1.44 - 29.10). There was no significant association between regimen complexity factors, relationship between health care provider and patient/caregiver, pattern of healthcare delivery and adherence to medication. Conclusion The adherence rate to anti-TB medication in this population was relatively high. The high rate of adherence was probably due structures that have been put in place to ensure that TB patients have access to TB treatment services even at the community level.

Conference:

1st International Scientific Conference

Publication Author(s):

DR. OSANJO GEORGE OYAMO